IL10 and colitis: Preclinical studies also suggested Bifidobacterium supplementation could alleviate colitis in mice receiving anti-CLTA-4 (Wang et al., 2018), and this was potentially mediated by gut microbiome optimization, thereby enhancing the expression of IL-10Ra and IL-10 of intestinal Treg cells and ultimately alleviating immune-related intestinal damages (Sun et al., 2020).