Mechanistic study demonstrated that Artemisia extract exerts an attenuate effect on IL-1β secretion and NLRP3 inflammasome activation in bone marrow-derived macrophages (BMDMs) and MSU-induced peritonitis mouse model by suppressing the ASC oligomerization and speck formation, and might be developed as a potential therapeutic drugs for inflammasome-mediated metabolic disorders, such as GA (57). This evidence concerns the gene NLRP3 and peritonitis.