RASGRP1 and osteoporosis: Five genes remained after the LASSO feature selection, and the formula for the osteoporosis risk score (ORS) was established as follows: ORS = 33.991 - 2.272 * ABCD2 - 6.201* RORA + 2.237 * ITK - 1.100 * CAMK4 + 0.466 * RASGRP1 (Figures 8B, C).