On the one hand, FGF-23, which has been shown to have intact activity in patients undergoing PD, can increase the expression and secretion of inflammatory factors (42, 43) and has been reported to activate local inflammation in organs via nuclear factor of activated T cells, FGF receptor 4 (FGFR4)/phospholipase C gamma (PLCγ), and other pathways (44), all of which increase its potential association with peritonitis. Here, FGF23 is linked to peritonitis.