Previously, a meta-analysis of 16 independent studies including 5,125 patients with depression and 8,399 controls showed that the FKBP5 rs1360780 and rs4713916 polymorphisms were associated with depression, but there was no significant association for FKBP5 rs9470080 or rs9296158 (36). This evidence concerns the gene FKBP5 and depressive symptom measurement.