There were no significant differences between non-stroke recurrent patients and stroke recurrent patients in terms of gender and age; however, there were significant differences in the side of the hemisphere (SOH; P = 0.014 < 0.05), blood homocysteine (HCY; P < 0.0 01), C-reactive protein (CRP; P < 0.001), neuron-specific enolase (NSE; P = 0.002 < 0.05), central neurospecific protein (S100β; P = 0.012 < 0.05), anticoagulation therapy (P < 0.001), proton pump inhibitor therapy (PPI; P = 0.007 < 0.05), dysphagia (P = 0.039 < 0.05), and stroke severity (SS; P < 0.001). The gene discussed is S100B; the disease is Stroke.