Projections from the BLA to mPFC are also directly involved in the regulation of anxiety-related behavior, and the Corticotrophin-releasing factor 1 (CRF1) receptors in mPFC layer V pyramidal cells, in which CRF1-inputs are majorly from BLA, are activated by exposure to stress (Liu et al., 2015). The gene discussed is CRHR1; the disease is Anxiety.