In the current study, our data provided evidence that TMP exhibited neurovascular restorative effects on stroke treatment via improving CBF, protecting NVU integrity, promoting endogenous neurogenesis and angiogenesis, inducing the A2 astrocytic polarization coupled with regulating AQP4 and Cx43 and activating FGF2/PI3K/AKT signals following ischemic stroke. Here, AQP4 is linked to stroke disorder.