By comparison with model rats, TMP (10, 20, 40 mg/kg) obviously upregulated the number of Ki67+/CD31+ cells in peri-infarct cortex and striatum (p < 0.05 or p < 0.01), demonstrating that TMP promoted cell proliferation and endothelia differentiation post-ischemia. Here, MKI67 is linked to ischemia.