However, while the above evidence indicates that endogenous Gq-GPCR activation in astrocytes promotes intracellular and synaptic processes that are expected to enhance memory, Reichenbach et al. (2018) show that inhibition of astrocytic P2YR1 is protective against spatial learning and memory impairment in the APP/PS1 mouse model of Alzheimer’s Disease (AD). The gene discussed is APP; the disease is Alzheimer disease.