The findings of administering mangosteen peel ethanol extract (250 and 500 mg/kg/day, 35 days) to male Wistar rats revealed that 500 mg/kg of ethanol extract of G. mangostana peel reduced isoniazid-induced liver damage in rats by lowering TGF-β1, SGPT level, and liver fibrosis (69). This evidence concerns the gene GPT and Hepatic fibrosis.