LRP1 and early-onset autosomal dominant Alzheimer disease: Typically, LDL receptor-related protein 1 (LRP1) transports Aβ across the blood-brain barrier; however, factors like aging, oxidative stress, and gene mutation impair LRP1 clearance, resulting in peptide buildup and aggregation, which play a crucial role in the pathogenesis of Alzheimer’s disease by causing neurotoxicity and cell death mostly through the generation of ROS (39, 41).