In the eye during experimental uveitis, TNF-α collects leukocytes, increases leukocyte adhesion to the vascular endothelium, activates macrophages and strains T cells, and promotes apoptosis of both established cells and infiltrating cells and previous studies have shown that TNF-α affects the JAK-STAT pathway in cells (36).  In addition, studies are showing that melatonin receptors have antibacterial properties (37, 38). This evidence concerns the gene TNF and uveitis.