CD34 and inflammatory bowel disease: Indeed, CD34 expression in the intestinal mucosa of IBD patients is significantly higher than that in healthy subjects (Tsiolakidou et al., 2008); inflammation is relatively mild in CD34 knockout mice belonging to the dextran sulfate-induced ulcerative colitis mouse model (Maltby et al., 2010); another report showed that the treatment with curcumin reduces the levels of CD34 immunoreactive capillaries and inflammatory cells in the intestinal inflammatory site compared with its levels in the control group (Hamed et al., 2022).