In T2DM the accumulation of fat in the adipose tissue leads to increased lipotoxicity which causes both beta-cell dysfunction and insulin resistance [6]. Zinc Alpha 2 glycoprotein (ZAGP), an adipokine that acts as a lipid-mobilizing factor, plays a crucial role in lipolysis in adipose tissue [7]. ZAGP is postulated to inhibit lipogenic enzymes and enhance the action of lipolytic enzymes in adipose tissue through various pathways. This evidence concerns the gene AZGP1 and type 2 diabetes mellitus.