FAS and obesity due to melanocortin 4 receptor deficiency: Active compounds such as 6-gingerol decreased obesity by changing the activities and expression levels of some lipid metabolism markers, such as FAS, ACC, 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), lecithin choline acyl transferase (LCAT), and lipoprotein lipase (LPL) (62).