Some molecular signals including insulin, Wnt, ELT-2, TGF-β, p38 MAPK, and PCD related signals have been identified to be involved in regulating the bacterial infection (Kurz and Tan, 2004; Irazoqui et al., 2008; Arvanitis et al., 2013; Zhi et al., 2017a; Head et al., 2017). This evidence concerns the gene INS and bacterial infectious disease.