The CXCL12 and chemokine receptors, CXCR4 and CXCR7, are the key factors that link cancer cells and their microenvironment, thus playing a crucial role in tumor initiation and progression [21], including the migration of prostate cancer cell lines such as PC3 and LNCaP [22]. Here, CXCL12 is linked to Familial prostate cancer.