The oral pretreatment for 12 days, with this extract or fraction (10–100 mg/kg bw), was able to protect the mice’s livers from hyperlipidemia-induced oxidative stress (decreased hepatic lipid peroxidation, protein carbonylation, and thiol group oxidation; restored hepatic GSH level; increased hepatic antioxidant enzymes activity (SOD, CAT, GPx, GR, and G6PD)) and lipid accumulation (reduced hepatic triglycerides and total cholesterol levels). The gene discussed is G6PD; the disease is hyperlipidemia.