This phenolic-rich fraction suppressed the hepatotoxic effects of hyperglycemia, reducing serum liver enzyme activities (ALT, AST, and ALP) and improving some hepatic biochemical parameters (reduced lipid peroxidation, protein carbonylation and nitration, iNOS level, and overexpression and activity of some antioxidant enzymes (GPx, SOD, and CAT) while increased GR activity, GSH content, and total antioxidant activity). The gene discussed is CAT; the disease is Hyperglycemia.