Interestingly, a previous in vivo experiment indicated that naringenin (50 mg/kg) downregulated ACE and mineralocorticoid receptor (indicators of hypertension) and also alleviated neuronal oxidative stress (indicator of neurological damage) in L-NG-nitro arginine methyl ester (L-NAME)-induced hypertensive rat [19]. The gene discussed is NR3C2; the disease is hypertensive disorder.