ACE and obesity due to melanocortin 4 receptor deficiency: In this study, different parts of sacred lotus including seed embryo, petal, stamen, old leaf, leaf stalk and flower stalk collected at different time periods were subjected to aqueous-based extraction and investigated regarding their TPCs, antioxidant activities and key enzyme inhibitions relevant to AD (BACE-1, AChE and BChE), hypertension (ACE), diabetes (α-glucosidase) and obesity (lipase).