JMJD6 and acute myeloid leukemia: This ET domain interacts with a variety of cellular proteins such as histone-lysine N-methyltransferase (NSD3) [18,19,20,21] and Jumonji domain-containing 6 (JMJD6) [22,23], whose interactions are implicated in acute myeloid leukemia (AML) and various solid tumors, respectively.