BRD4 and breast carcinoma: In the breast cancer cell line HeLa, a preferential alteration of Brd4-dependent genes (including MYC, p21, and AREG) but not other Brd4-independent genes (such as FAS, FGFR1, and TYRO3) was induced by MZ1 relative to JQ1, which was consistent with the selective suppression of Brd4 by MZ1 [121].