PRR antagonist PRO20 binds to all PRR sites of prorenin, similar to HRP (L1PTDTASFGRILLKKMPSVR20), according to Li et al. [9]; a complete block of prorenin-induced phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2) can be achieved by this compound, as well as an improvement in hypertension caused by DOCA salts [17]. Here, MAPK3 is linked to Hypertension.