In hepatitis B virus (HBV)-associated hepatocellular carcinoma, the accumulation of ROS induced by HBV enhances the combination of IQGAP1 and Rac1, which activate the Rac1 and Src/FAK pathway to enhance anoikis resistance and the migration of hepatoma cells [109]. The gene discussed is RAC1; the disease is hepatocellular carcinoma.