To confirm whether the combination of GFG and CTX inhibits the H22 tumor growth by affecting the expression of angiogenesis-related proteins, the protein levels of matrix metalloproteinase-9 (MMP-9), metalloproteinase-2 (MMP-2), VEGF, basic fibroblast growth factor (bFGF), B-cell lymphoma-2 (Bcl-2) and Bcl-2 assayed X protein (Bax) were determined by western blotting. This evidence concerns the gene MMP2 and neoplasm.