MnTE-2-PyP inhibited the Smad2/3 signaling pathway and the expression of matrix metalloproteinase 2 (MMP-2) and 9 (MMP-9) in colorectal cancer cells, reducing TGF-β-induced EMT and thus invasion of the colorectal and other cancer cells [43,44]. The gene discussed is SMAD2; the disease is colorectal cancer.