Lipid subclasses in the Cushing study changed differently from the other two interventions, in that PS was significantly increased after surgery, which exhibited that as a traditional treatment of Cushing’s syndrome, removing the ACTH-secreting pituitary adenomas will lead to weight loss but not to a decrease in all eight lipid subclasses. The gene discussed is POMC; the disease is Cushing syndrome due to macronodular adrenal hyperplasia.