CXCL8 and neoplasm: In another pilot study carried out among 26 patients, who were randomized to receive treatment 14 days before surgery (an ONS with immunonutrition versus a standard ONS), it was shown that immunonutrition can influence the expression of inflammatory cytokines (TNF-alfa, IL8, or chemokines) and the infiltration of leukocytes into the tumor tissue [24].