APOE and Alzheimer disease: After supplementation with anserine and carnosine (54 subjects; 750 and 250 mg/day for 12 weeks), no significant effect on cognitive function was observed in patients with a mild form of cognitive dysfunction; however, in a follow-up analysis, it was found that there was an improvement in cognitive function in participants who are Apo E4 carriers (Apo E4 functions as a risk factor for AD development).