PTGS2 and Intervertebral disk degeneration: In a report using a rat model of chronic compression of the dorsal root ganglion (CCD) to reproduce the neuropathic pain caused by intervertebral disc degeneration (IVDD), HTyr (acutely administered intrathecally in the spinal cord) reduced the levels of some inflammatory molecules activated by the NF-kB pathway, i.e., cyclooxygenase-2 (COX-2), NLRP3, nitric oxide synthase (iNOS), and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4) [230].