PPARGC1A and sarcopenia: Besides preventing the induction of the sarcopenia-related markers HDAC4, MyoD, myogenin, and rescuing the downregulation of PGC1α, the co-administration of both ingredients attenuated the reduction of MyHC isoforms, downregulated the expression of Atrogin-1 and MuRF1, prevented age-induced macrophage infiltration, and activated the insulin-dependent PI3K/Akt pathway in gastrocnemius muscle and adipose tissue [297].