Similarly, in primary rat astrocytes activated by LPS, HTyr, in a mix with tyrosol, inhibited matrix metalloproteinase-2 (MMP-2; also known as gelatinase A) and MMP-9 (gelatinase B); these are two proteolytic enzymes involved in inflammatory processes and in MS, since, for instance, MMP-9 increases blood–brain barrier permeabilization to leukocytes infiltration into the CNS [160]. Here, MMP2 is linked to myeloid sarcoma.