In this context, HTyr butyrate has been shown to inhibit the apoptosis induced in SH-SY5Y cells by the PD-related neurotoxin 6-hydroxydopamine (6-OHDA) through activation of the Nrf2/heme oxygenase-1 axis (Nrf2/HO-1) [143]. Here, HMOX1 is linked to Parkinson disease.