As shown in Figure 4A,B, compared with the CMC-Na+Saline group, rotenone treatment markedly increased the expression of Iba-1 in the nigrostriatal area of PD mice (p < 0.001), whereas the expression of Iba-1 in the mice of the L. plantarum CCFM405 group was markedly lower compared to that in the model group (p < 0.01). This evidence concerns the gene AIF1 and Parkinson disease.