In the context of NAFLD, many myokines have the capacity to control glucose homeostasis by activating or inhibiting glucose metabolism pathways, such as insulin sensitivity, glycogenesis, gluconeogenesis and glycolysis; thus, having an impact on both glucose storage, in the form of glycogen, and on its production from glycogen or non-carbohydrate compounds for energy needs. This evidence concerns the gene INS and metabolic dysfunction-associated steatotic liver disease.