A study performed on type 2 diabetic rat adipocytes [42] reported that the main component of F4, β-sitosterol, besides controlling hyperglycaemia and insulin resistance by upregulating GLUT-4 and PPARγ, was able to restore the normal level of proinflammatory cytokines, such as leptin, resistin, TNF-α, and IL-6, but, on the other hand, it was able to increase cytokines such as adiponectin, which acts positively on metabolism with its anti-inflammatory activity. Here, RETN is linked to Insulin resistance.