Of note, the anti-inflammatory action exerted by CP on specific cytokines such as Rantes, MCP-1, KC, eotaxin, and GM-CSF could represent an effective mechanism to attenuate or ameliorate insulin resistance and, more generally, the glucose intolerance characteristic of obesity, in addition to ameliorating people’s overall state of health. Here, CALCA is linked to obesity due to melanocortin 4 receptor deficiency.