CCL2 and obesity due to melanocortin 4 receptor deficiency: Of note, the anti-inflammatory action exerted by CP on specific cytokines such as Rantes, MCP-1, KC, eotaxin, and GM-CSF could represent an effective mechanism to attenuate or ameliorate insulin resistance and, more generally, the glucose intolerance characteristic of obesity, in addition to ameliorating people’s overall state of health.