LDLR and obesity due to melanocortin 4 receptor deficiency: We used low-density lipoprotein receptor knock-out Leiden mice (Ldlr−/−.Leiden), an HFD-induced mouse model of obesity that develops obesity-associated dysfunctions, such as WAT inflammation, insulin resistance, atherosclerosis, and hypertension [39,40,41,42,43,44,45,46,47,48].