PTGS2 and Familial prostate cancer: Toxicity towards prostate cancer cells compared with DU145 cells.Exhibits apoptotic effects in DU145 cells by stimulating a pre-existing apoptotic pathway.Activates mitogen-activated protein kinase (MAPK) inhibition.BCR/ABL kinase inhibition.NF-Κβ inactivation.Cyclooxygenase-2 (COX-2) Down-regulation.