Several mechanisms have been proposed behind maternal HF diet-primed hypertension programming, such as an aberrant renin-angiotensin-aldosterone system (RAAS) [5], increased oxidative stress [21], deficient nitric oxide [22], impaired sodium transporters [23], epigenetic regulation [24], and dysregulated nutrient-sensing signals [21]. This evidence concerns the gene SLC5A4 and hydrops fetalis.