In response to different stimuli such as TNF-α, bacterial lipopolysaccharide (LPS), hyperglycemia, shear stress, oxidative stress, and hypoxia/reperfusion, IκB is degraded, and NF-κB rapidly activates and translocates into the nucleus to initiate the transcription of immune and inflammatory genes [61]. The gene discussed is NFKB1; the disease is Hyperglycemia.