In addition, this state of inflammation leads to hyperinsulinemia, which in turn promotes insulin resistance with the increased production of IGF-1 (insulin-like growth Factor-1) and hormone imbalances, including an increase in estrogens as a result of androgen conversion at the adipose tissue level, which in turn stimulates the proliferation of mammary gland and endometrial epithelial cells [25,26]. The gene discussed is IGF1; the disease is Insulin resistance.