INS and Hyperglycemia: These include (1) improving insulin levels, (2) attenuating hyperglycemia and hyperlipidemia, (3) restoring normal cardiac metabolism (i.e., stimulating glucose uptake and oxidation and FA oxidation), (4) activating the cardiac Nrf2/antioxidant axis and (5) inhibiting cardiac NF-κB p65/inflammatory cytokines axis.