NFKB1 and rheumatoid arthritis: Moreover, in vitro, experimental, and clinical studies have confirmed the ability of IKAB and other extracts of B. serrata to ameliorate psoriasis, atherosclerosis, asthma, colitis, rheumatoid arthritis, and osteoclastogenesis by suppressing NF-κB and inflammatory cytokine production [95,96,97,98], a phenomenon reviewed by Ammon [34].