The efficacy of CK has been extended to inhibit palmitate-induced skeletal muscle apoptosis by repressing endoplasmic reticulum stress [12] and to stimulate the secretion of glucagon-like peptide-1 (GLP1), a gastrointestinal hormone to ameliorate impaired glucose tolerance in type 2 diabetes db/db mice [13]. This evidence concerns the gene GCG and type 2 diabetes mellitus.