↑ p53↑ caspase-3↑ Bax↑ P38↑ CytoC↑ P21Cip1↑ P27Kip1↓ CDK2, c-Myc↑ G0/G1 phase↑ inhibition of tumor growth↓ VEGF. The gene discussed is CDK2; the disease is neoplasm.