Interestingly, CAT- and SOD-producing S. thermophilus CRL 807 were administered to mice with chronic colitis as a suspension in saline solution or in fermented milk in a study conducted by del Carmen et al. [25], which revealed that these gm probiotics in fermented milk were more effective than in saline solution; for instance, the former significantly alleviated intestinal damage compared to the parental strain, but the latter showed almost no superiority. The gene discussed is CAT; the disease is Chronic colitis.