When analyzing the prevalence in different geographical regions of the world, the prevalence of SR wheat allergy in African regions was the highest, while SRPD wheat allergy or wheat allergy confirmed by FC in European region was the highest, wheat allergy for SPT or sIgE positive for regions of Americas was the highest, and significant difference (p < 0.05) was only found in subgroup analysis of SRPD wheat allergy and wheat allergy for SPT positive. The gene discussed is AGXT; the disease is wheat allergic reaction.