In our previous work, insulin sensitivity and body weight were improved by TRF, although there was little difference in food intake between the HF-AL and HF-TRF groups [25]; we hypothesize that TRF triggers a change in nutrient (e.g., dietary fat) absorption due to shortened feeding times, which may explain the improvements in metabolic health because of TRF and will lay the foundation for future studies examining host metabolic health. The gene discussed is INS; the disease is hydrops fetalis.