PTGS2 and chronic obstructive pulmonary disease: Additionally, curcumin treatment has been shown to mitigate inflammation through the inhibition of the NLR family pyrin domain containing 3 (NLRP3) inflammasome in murine bone-marrow-derived macrophages and the activation of production of cyclooxygenase 2 (COX-2) in murine models of chronic obstructive pulmonary disease (COPD), an enzyme associated which the biosynthesis of proinflammatory eicosanoid synthesis [49,50].