On the other hand, it was reported that CT-1 expressions were increased in the liver of patients with NAFLD and in steatotic livers from genetic and diet-induced diabetic animal models [25]; however, without considering the confounding factors, such as obesity and diabetes, the levels of CT-1 in NAFLD were still obscure. This evidence concerns the gene CTF1 and obesity due to melanocortin 4 receptor deficiency.