At our department, the repeated thyroid function test (TSH 27.7 mUI/L [0.4–4], fT3 2.55 ng/L [2.5–70.70], fT4 0,92 ng/dL [0.70–1.70]) confirmed overt hypothyroidism; the levels of thyroglobulin, calcitonin and anti-thyroglobulin antibodies were normal, however there was a weak positive result for anti-thyroperoxidase antibodies (35 UI/mL, range of normal up to 10). This evidence concerns the gene TG and hypothyroidism.