In this report, we review the role of alarmins in the pathophysiology of food allergies, including IgE-mediated food allergy (such as cow’s milk allergy (CMA)), non-IgE mediated food allergy (such as non-IgE cow’s milk protein allergy (CMPA), food protein-induced allergic proctocolitis (FPIAP), and food protein-induced enterocolitis syndrome (FPIES)) and mixed IgE cellular-mediated food allergy (such as eosinophilic esophagitis). The gene discussed is IGHE; the disease is food allergy.