Subsequently, Noti et al. [38] revealed that mice, epicutaneously sensitized with OVA or peanut on AD-like skin lesion followed by intragastric antigen-specific challenge, showed expanded TSLP-elicited basophils in the skin, promoting antigen-specific Th2 cytokine responses, elevated antigen-specific serum IgE levels, and accumulated mast cells in the intestine, favoring the development of intestinal food allergy. This evidence concerns the gene IGHE and Alzheimer disease.