High incidence of MYD88 variants has been detected in lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia (LPL/WM) (~95%), and it is also occasionally reported in diffuse large B-cell lymphoma (DLBCL) (20~30%), CLL/SLL (3~10%), and marginal zone B-cell lymphoma (MZBL) (5~7%), but rarely reported in other subtypes [13,14,15]. The gene discussed is MYD88; the disease is diffuse large B-cell lymphoma.