High incidence of MYD88 variants has been detected in lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia (LPL/WM) (~95%), and it is also occasionally reported in diffuse large B-cell lymphoma (DLBCL) (20~30%), CLL/SLL (3~10%), and marginal zone B-cell lymphoma (MZBL) (5~7%), but rarely reported in other subtypes [13,14,15]. Here, MYD88 is linked to B-cell chronic lymphocytic leukemia.