Notably, atypical CLL/SLL was shown to be associated with an inferior outcome in previous studies, combined with the significant correlation between MYD88 variants and atypical immunophenotypes in this study, suggesting the potential influence of immunophenotype grouping bias on the prognostic impact of MYD88 variants [19,26]. This evidence concerns the gene MYD88 and B-cell chronic lymphocytic leukemia.