Additionally, growth differentiation factor-15 (GDF-15) [61], associated with upregulation of inflammatory pathways, and angiopoietin-2 [62], related to vascular instability, were independently associated with poor short- [61] and long-term mortality and reperfusion success [62] in AMI-CS patients, in two subanalyses of the IABP-SHOCK II Trial. The gene discussed is GDF15; the disease is Cowden syndrome 1.