CD274 and neoplasm: Numerous recent clinical trials of immune checkpoint inhibitors for the treatment of gastric cancer reported that the combined positive score (CPS), defined as the number of cells stained positive for PD-L1 (tumor cells, lymphocytes, macrophages) as a proportion of the total number of tumor cells multiplied by 100, is useful for predicting treatment responses [10,13,14,26,27,28,29,30].