High GAD65-Ab levels (at least 100-fold) have been found in autoimmune neurological disorders (e.g., stiff-person syndrome, cerebellar ataxia, and limbic encephalitis), sporadic drug-resistant temporal lobe epilepsy in children and adults, and in the subgroup of patients with T1DM who develop seizures. The gene discussed is GAD2; the disease is aceruloplasminemia.