Interestingly, the temporal profile of IL-6 points to a distinctly different inflammatory profile in sports-related concussion (SRC) and military concussion versus the general unselected population with mTBI; athletes show early acute elevation (<8 h) with a return to baseline within 48 h, highlighting an earlier resolution of the inflammatory response in comparison with the general unselected population showing alterations lasting up to six months after injury. This evidence concerns the gene IL6 and concussion.